The melatonin receptor 1A (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis
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چکیده
منابع مشابه
The melatonin receptor 1A (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis.
BACKGROUND Experimental evidence indicate that melatonin regulates some renal tubular functions via specific melatonin receptors (MTNRs) located in the kidney of several avian and mammalian species, including humans. We hypothesized that single nucleotide polymorphisms (SNPs) in the melatonin receptor 1A gene (MTNR1A) might influence the risk of calcium nephrolithiasis. METHODS We performed a...
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and Implications Human and sheep Melatonin receptor 1a (MTNR1A) gene information was used to clone a portion of the coding region of this gene in pigs, and to identify polymorphisms of the gene for its assignment to both the genetic linkage and physical maps. MTNR1A maps to pig chromosome 17, establishing a new region of conserved synteny between this chromosome and human chromosome 4. Furtherm...
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The aim of the present work was to explore and characterize the different polymorphic variants of exon II region of MTNR1A gene in 31Corriedale sheep of Kashmir. Genomic DNA was extracted and subjected to PCR for the amplification of the main part of exon II of the ovine MTNR1A gene. PCR products were subjected to restriction enzyme (RE) digestion by MnlI restriction enzyme and depending upon n...
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The objective of this study was to evaluate the relationship between polymorphism at the MnlI site of MTNR1A gene and production traits of Shal and Romanov crossbreeding. The crossbreeding between Shal and Romanov was done on 600 Shal ewes. For this reason, Shal ewes were laparoscopically and artificially inseminated with the semen of Romanov breed. For the preparation of genomic DNA, a total o...
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BACKGROUND/AIMS Melatonin receptor 1A (MTNR1A) gene is a regulator of circadian rhythms and reproductive processes. The MTNR1A gene is also a potential candidate gene of polycystic ovary syndrome (PCOS). The aim of the present study was to determine whether or not the MTNR1A gene polymorphism is associated with a predisposition to PCOS. METHODS The single nucleotide polymorphism (SNP) rs21198...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2011
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfr216